In certain people with Parkinson’s disease, mutations in the parkin gene disrupt the proper function of dopamine, the brain chemical that controls body movement.
The finding could lead to new treatments and screening methods for the disease, according to the University at Buffalo researchers.
Using live human neurons in the laboratory, the team found that parkin mutations hinder the actions of dopamine and produce more “free radicals,” harmful molecules that destroy dopamine-laden brain cells, leading to Parkinson’s disease.
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